873200-51-2Relevant academic research and scientific papers
Efficient relaxivity enhancement in dendritic gadolinium complexes: Effective motional coupling in medium molecular weight conjugates
Fulton, David A.,O'Halloran, Mark,Parker, David,Senanayake, Kanthi,Botta, Mauro,Aime, Silvio
, p. 474 - 476 (2005)
Enhancement of the relaxivities of Gd-based MRI contrast agents is achieved by placing the metal ion at the barycentre of the molecular complex in order to improve motional coupling.
CONTRAST AGENTS ENDOWED WITH HIGH RELAXIVITY
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Page/Page column 44-45, (2008/06/13)
The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhdroxylated chain, that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity.
