873206-85-0Relevant academic research and scientific papers
Structure-based design, synthesis and in vitro characterization of potent 17β-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone
Moeller, Gabriele,Deluca, Dominga,Gege, Christian,Rosinus, Andrea,Kowalik, Dorota,Peters, Olaf,Droescher, Peter,Elger, Walter,Adamski, Jerzy,Hillisch, Alexander
, p. 6740 - 6744 (2009)
In search for specific drugs against steroid-dependent cancers we have developed a novel set of potent inhibitors of steroidogenic human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD 1). The X-ray structure of 17β-HSD 1 in complex with estradiol served
NOVEL 2-SUBSTITUTED D-HOMO-ESTRA-1,3,5(10)-TRIENES AS INHIBITORS OF 17?-HYDROXYSTEROID DEHYDROGENASE TYPE 1
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Page/Page column 17, (2008/06/13)
The invention relates to novel 2-substituted D-homo-estra-1,3,5(10)-trienes of general formula (I) wherein R2 represents a C1-C8 alkyl, a C1-C8 alkyloxy group or a halogen atom, R13 represe
