87325-65-3Relevant academic research and scientific papers
Total synthesis of cyclomarins A, C and D, marine cyclic peptides with interesting anti-tuberculosis and anti-malaria activities
Barbie, Philipp,Kazmaier, Uli
, p. 6036 - 6054 (2016/07/06)
Cyclomarins are cyclic heptapeptides containing four unusual amino acids. New synthetic protocols toward their synthesis have been developed, leading to the synthesis and biological evaluation of three natural occurring cyclomarins. Interestingly, cyclomarins address two completely different targets: Clp C1, a subunit of the caseinolytic protease of Mycobacterium tuberculosis (MTB), as well as PfAp3Ase of Plasmodium falciparum. Therefore, cyclomarins are interesting lead structures for the development of drugs against tuberculosis and malaria.
Peptides containing γ,δ,-dihydroxy-L-leucine
Edagwa, Benson J.,Taylor, Carol M.
supporting information; experimental part, p. 4132 - 4136 (2009/09/26)
(Chemical Equation Presented) (±)-Dehydroleucine was prepared and resolved by porcine kidney acylase. Under the conditions of the Sharpless asymmetric dihydroxylation (SAD), employing AD-mix-α, Nα- carbobenzyloxy-(2S)-4,5-dehydroleucine methyl ester (16)
The total synthesis of eponemycin
Schmidt,Schmidt
, p. 300 - 304 (2007/10/02)
Eponemycin, an antibiotic with a highly potent and specific antitumor activity against B16 melanoma cells in vivo, has been synthesized. The framework of the western half of the molecule was built up from N-trityl- γ,δ-didehydroleucinal and the dilithium
