873302-36-4

Usage

Uses

Used in Pharmaceutical Industry:
3-IODO-5-METHOXY-PYRIDINE is used as a key intermediate in the synthesis of various pharmaceutical drugs. Its unique structure and properties contribute to the development of new drugs with improved therapeutic effects.
Used in Agrochemical Industry:
3-IODO-5-METHOXY-PYRIDINE is utilized as a building block in the synthesis of agricultural chemicals. Its versatile nature allows for the creation of compounds with potential applications in crop protection and pest control, enhancing agricultural productivity and sustainability.

InChI:InChI=1/C6H6INO/c1-9-6-2-5(7)3-8-4-6/h2-4H,1H3

Upstream product

• 50720-12-2 3-bromo-5-methoxypyridine 
• 64436-92-6 3-amino-5-methoxypyridine 

Relevant academic research and scientific papers

3-iodine-5-methoxypyridine synthesis method

The invention relates to a 3-iodine-5-methoxypyridine synthesis method, and mainly aims to solve the technical problem of simplification of the 3-iodine-5-methoxypyridine synthesis method. The 3-iodine-5-methoxypyridine synthesis method is characterized by including the step: adding sodium nitrite into ice-salt baths of 3-amino-5-methoxypyridine and sulfuric acid solution to react to generate diazonium salt; adding iodide, replacing diazonium of the diazonium salt with iodine negative ions, taking strong alkaline solution as reaction liquid, adjusting pH (potential of hydrogen) to be 8-9, performing ethyl acetate extraction, performing spin drying, purifying coarse products by a chromatographic column to obtain a target product 1, namely, the 3-iodine-5-methoxypyridine. The 3-iodine-5-methoxypyridine mainly serves as a medical intermediate.

Rapid and efficient copper-catalyzed finkelstein reaction of (hetero)aromatics under continuous-flow conditions

A general, rapid, and efficient method for the copper-catalyzed Finkelstein reaction of (hetero)aromatics has been developed using continuous flow to generate a variety of aryl iodides. The described method can tolerate a broad spectrum of functional groups, including N-H and O-H groups. Additionally, in lieu of isolation, the aryl iodide solutions were used in two distinct multistep continuous-flow processes (amidation and Mg-I exchange/nucleophilic addition) to demonstrate the flexibility of this method.