873306-44-6

Upstream product

• 14742-32-6 2-amino-5-phenylfuran-3-carbonitrile 
• 70-11-1 α-bromoacetophenone 
• 18031-97-5 4-amino-6-phenylfuro[2,3-d]pyrimidine 

Downstream Products

• 1073135-81-5 5-bromo-4-chloro-6-phenylfuro[2,3-d]pyrimidine 
• 1073136-10-3 cis/trans-({3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}oxy)acetic acid tert-butyl ester 
• 1092938-73-2 methyl (3-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetate 
• 1093386-36-7 ethyl (-)-2-{(2R)-3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]-2-methylpropyloxy}acetate 
• 1093066-22-8 (6R)-6-{[5-(4-Ethylcyclohexyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid 
• 1092938-27-6 tert-butyl (6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate 
• 1092938-55-0 (6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid 
• 1092938-16-3 tert-butyl (6R)-6-[(5-cyclopent-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate 
• 1092938-13-0 tert-Butyl (6R)-6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate 
• 1092938-75-4 (3-{[5-(5-Ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid 
• 1092938-95-8 methyl {3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]phenoxy}acetate 
• 1092938-82-3 tert-butyl (6R)-6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate 
• 1073136-04-5 tert-butyl rac-3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]-1-piperidine carbamate 
• 1073136-09-0 cis/trans-3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]cyclohexanol 

Relevant academic research and scientific papers

Novel, Cyclically Substituted Furopyrimidine Derivatives and Use Thereof

The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

SUBSTITUTED FUROPYRIMIDINES AND USE THEREOF

The present application relates to novel substituted furopyrimidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular diseases.

TRISUBSTITUTED FUROPYRIMIDINES AND USE THEREOF

The invention relates to the novel 4,5,6-trisubstituted furo[2,3-d]pyrimidine derivatives of formula (I), to methods for their production, their use in the treatment and/or prophylaxis of diseases and their use in the production of drugs for the treatment

Novel, Acyclically Substituted Furopyrimidine Derivatives and Use Thereof

The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

FURANOPYRIMIDINES

The present invention relates to furanopyrimidine compounds having the general Formula (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula (I), methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula (I). The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula (I).