873316-17-7Relevant articles and documents
Sequencing cross-metathesis and non-metathesis reactions to rapidly access building blocks for synthesis
Sirasani, Gopal,Paul, Tapas,Andrade, Rodrigo B.
experimental part, p. 2197 - 2205 (2011/04/22)
The olefin cross-metathesis reaction has been sequenced with four common organic transformations in a one- or two-pot manner to rapidly access useful building blocks. Those reactions are: (1) phosphorus-based olefination (e.g., Wittig and Horner-Wadsworth-Emmons); (2) hydride reduction; (3) Evans propionate aldol reaction; (4) Brown allyl- and Roush crotyl-boration. The products of these reactions include stereodefined 2,4-dienoates, trans allylic alcohols, syn-propionate aldols, and chiral non-racemic homoallylic alcohols, respectively. Many of these intermediates have been carried further to natural products, demonstrating the utility of the methodology.
Cytotoxic activity of (S)-goniothalamin and analogues against human cancer cells
De Fatima, Angelo,Kohn, Luciana K.,De Carvalho, Joao Ernesto,Pilli, Ronaldo A.
, p. 622 - 631 (2007/10/03)
(R)- and (S)-Goniothalamin (1) and analogues 2-9 were efficiently prepared in high overall yield and enantiomeric purity, and their cytotoxic activities were evaluated against eight human cancer cell lines. A structure-activity relationship study (SAR) al
