873414-22-3

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 49799-48-6 1H-1,5-benzodiazepine-2,4(3H,5H)-dione 
• 62985-40-4 (4'-nitrobenzo)[1',2'-d]-1,4-diazacycloheptane[2,3-d]-5,7-dione 

Downstream Products

• 952313-53-0 N-(2''-hydroxyl-3'',5''-dibromophenyl-methylene-yl)-4'-iminobenzol[1',2'-d]-1,4-diazacycloheptane[2,3-d]-5,7-dione 
• 1418197-61-1 N-(2'-hydroxyl-3'-bromophenyl-methylene-yl)-4'-iminobenzo[1',2'-d]-1,4-diazacycloheptane[2,3-d]-5,7-dione 
• 1418197-62-2 N-(2'-hydroxyl-4'-chlorobenzene-methylene-yl)-4'-iminobenzo[1',2'-d]-1,4-diazacycloheptane[2,3-d]-5,7-dione 

Relevant academic research and scientific papers

Synthesis and anticonvulsant activity of some novel 7-(benzylamino) -1H-benzo[b][1,4]diazepine-2,4(3H, 5H)-dione derivatives

A series of novel 7-(benzylamino)-1H-benzo[b][1,4]diazepine-2,4(3H, 5H)-dione derivatives were synthesized and screened for their anticonvulsant activities by the maximal electroshock (MES) test, subcutaneous pentylenetetrazol (scPTZ) test, and their neurotoxicity was evaluated by the rotarod neurotoxicity test (Tox). The study showed that the compound 8c (7-(4-fluorobenzylamino)-1,5-dimethyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione) was the most promising compound, with median effective dose (ED50) of 36.5 mg/kg, and protective index (PI) values of 4.5 in the MES test. In the scPTZ test, compound 8c also exhibited better anticonvulsant activity (ED50 = 68.2 mg/kg), and the ED50 values of compounds 8c were smaller than that of the reference antiepileptic drugs carbamazepine (ED50 CloseSPigtSPi 100 mg/kg), phenytoin (ED50 CloseSPigtSPi 300 mg/kg), and sodium valproate (ED50 = 149 mg/kg). The possible structure activity relationship was discussed.

Synthesis and fluorescence studies of nine 1,5-benzodiazepine-2,4-dione derivatives: Dual emission and excimer fluorescence

The photophysical properties of nine 1,5-benzodiazepine-2,4-dione (BZD) derivatives were investigated using absorption and fluorescence spectral techniques in dimethyl sulfoxide. The trend of red shifts caused by the substitutions had full compliance with the trend of decreasing the calculated band gap (ΔELUMO-HOMO) by semi-empirical AM1 and DFT/B3LYP/6-311 + G* computational methods. The positive solvatochromism of BZD a demonstrated the π–π* nature of the singlet excited state. Dual fluorescence was observed in the emission spectra of BZD f and g, while their spectrum in different concentration showed only one peak short wavelength (SW) in dilute solutions. The main peak in SW around 370 nm was attributed to the monomer of BZD (f* or g*) and the broader emission shifted to the visible region around 400 nm in middle wavelength (MW) to the intermolecular excimer emission of BZD ([f/f]*or [g/g]*). The observed phenomena, such as solvatochromism, dual fluorescence, some red shifts caused by substitution, and larger Stokes shift indicated the existence of intramolecular charge transfer (ICT) in the BZDs series. The phosphorescence emission of the BZDs demonstrated their intersystem crossing (ISC) process.

Biological interaction between copper(II) complex and nucleosides

A copper-coordinated complex based on 7-membered amide cycle has been designed and synthesized. Its binding properties for various nucleosides, guanosine-5'-diphosphate (GDP), uridine-5'-diphosphate (UDP), inosine-5'- diphosphate (IDP) and guanosine-5'-tr

Anion recognition based on phenolic hydroxyl group in competitive media

Two novel artificial receptors, one containing phenolic hydroxyl group and diamide (1), the other only containing diamide (2), were designed and synthesized. The binding ability evaluated by UV-vis and fluorescence titration experiments in dry DMSO reveal

A supramolecular optic sensor for selective recognition AMP

Cu-coordinated complex based on 7-membered amide cycle has been designed and synthesized. And its binding ability with nucleotides (AMP, adenosine 5′-monophosphate; ADP, adenosine 5′-diphosphate; ATP, adenosine 5′-triphosphate) has been studied by UV-vis