873414-22-3

Basic information

• Product Name: 7-amino-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione
• CAS NO: 873414-22-3
• Molecular Formula: C₉H₉N₃O₂
• Molecular Weight: 191.18936
• Mol File: 873414-22-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 7-amino-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 7-amino-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione(873414-22-3)
• EPA Substance Registry System: 7-amino-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione(873414-22-3)

Safety Data

• Hazardous Substances Data: 873414-22-3(Hazardous Substances Data)

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 49799-48-6 1H-1,5-benzodiazepine-2,4(3H,5H)-dione 
• 62985-40-4 (4'-nitrobenzo)[1',2'-d]-1,4-diazacycloheptane[2,3-d]-5,7-dione 

Downstream Products

• 952313-53-0 N-(2''-hydroxyl-3'',5''-dibromophenyl-methylene-yl)-4'-iminobenzol[1',2'-d]-1,4-diazacycloheptane[2,3-d]-5,7-dione 
• 1418197-61-1 N-(2'-hydroxyl-3'-bromophenyl-methylene-yl)-4'-iminobenzo[1',2'-d]-1,4-diazacycloheptane[2,3-d]-5,7-dione 
• 1418197-62-2 N-(2'-hydroxyl-4'-chlorobenzene-methylene-yl)-4'-iminobenzo[1',2'-d]-1,4-diazacycloheptane[2,3-d]-5,7-dione 

Relevant articles and documents

Synthesis and anticonvulsant activity of some novel 7-(benzylamino) -1H-benzo[b][1,4]diazepine-2,4(3H, 5H)-dione derivatives

A series of novel 7-(benzylamino)-1H-benzo[b][1,4]diazepine-2,4(3H, 5H)-dione derivatives were synthesized and screened for their anticonvulsant activities by the maximal electroshock (MES) test, subcutaneous pentylenetetrazol (scPTZ) test, and their neurotoxicity was evaluated by the rotarod neurotoxicity test (Tox). The study showed that the compound 8c (7-(4-fluorobenzylamino)-1,5-dimethyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione) was the most promising compound, with median effective dose (ED50) of 36.5 mg/kg, and protective index (PI) values of 4.5 in the MES test. In the scPTZ test, compound 8c also exhibited better anticonvulsant activity (ED50 = 68.2 mg/kg), and the ED50 values of compounds 8c were smaller than that of the reference antiepileptic drugs carbamazepine (ED50 CloseSPigtSPi 100 mg/kg), phenytoin (ED50 CloseSPigtSPi 300 mg/kg), and sodium valproate (ED50 = 149 mg/kg). The possible structure activity relationship was discussed.

Biological interaction between copper(II) complex and nucleosides

A copper-coordinated complex based on 7-membered amide cycle has been designed and synthesized. Its binding properties for various nucleosides, guanosine-5'-diphosphate (GDP), uridine-5'-diphosphate (UDP), inosine-5'- diphosphate (IDP) and guanosine-5'-tr

A supramolecular optic sensor for selective recognition AMP

Cu-coordinated complex based on 7-membered amide cycle has been designed and synthesized. And its binding ability with nucleotides (AMP, adenosine 5′-monophosphate; ADP, adenosine 5′-diphosphate; ATP, adenosine 5′-triphosphate) has been studied by UV-vis