87342-71-0Relevant academic research and scientific papers
Kinetic resolution of diiron acyl complexes - An approach to asymmetric bicyclic β-lactams
Gilbertson, Scott R.,Lopez, Omar D.
, p. 1116 - 1119 (2007/10/03)
Kinetic resolution is achieved in the reaction of racemic diiron complexes like 1 with the chiral nitrone (-)-2. Oxidative removal of the metal and reductive cleavage of the N-O bond provides β-amino acids. This sequence was used in the synthesis of β-ami
Olivanic Acid Analogues. Part 2. Total Synthesis of Some C(6)-Substituted 7-Oxo-1-azabicyclohept-2-ene-2-carboxylates
Bateson, John H.,Quinn, Alison M.,Smale, Terence C.,Southgate, Robert
, p. 2219 - 2234 (2007/10/02)
A number of 6-substituted 7-oxo-1-azabicyclohept-2-ene-2-carboxylates related to the olivanic acids were prepared from the phosphorane (32).Generation of the anion α to the azetidin-2-one carbonyl group, followed by reaction with electrophiles and intramolecular cyclisation using the Wittig procedure gave the bicyclic products; in all cases the thermodynamically favoured trans-stereochemisty about the azetidinone ring predominated.In contrast, some less readily available cis-substituted analogues were obtained from the cyclohexa-1,4-diene derived phosphorane (61).The synthetic utility of a masked acetonyl ester group for preparing the free acids of these azabicycloheptene ring systems is described.
Synthesis and Stereochemistry of 3-(α-Hydroxybenzyl)-1,4-diphenyl-2-azetidinones
Otto, Hans-Hartwig,Mayrhofer, Roswitha,Bergmann, Hans-Joachim
, p. 1152 - 1161 (2007/10/02)
Aldol reaction between benzaldehydes and 1,4-diphenyl-2-azetidinones 1 catalyzed by lithium diisopropylamide results in formation of the title compound The reactions give satisfactory yields and high diastereoselectivity at three centres in forming the αS
