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Synthesis of some thioxopyrimidines, thiazolopyrimidines, thiazolodipyrimidines and pyrazolothiazolopyrimidines
Mobinikhaledi,Foroughifar,Ghorbani
, p. 1713 - 1719 (2005)
Thioxopyrimidines 4(a-c) were synthesized by using the Biginelli three-component cyclocondensation reaction of an appropriate β-diketone, arylaldehyde, and thiourea. Reaction of thioxopyrimidines 5 with bromomalononitrile under strong basic solution afforded thiazolopyrimidines 7(a-c). On condensation of thiazolopyrimidines 7 with hydroxylamine hydrochloride in acetic acid and in the presence of sodium acetate thiazolodipyrimidines 8(a-b) were obtained. However reaction of 7 with formic acid gave the corresponding pyrazolothiazolopyrimidine 9a. Copyright Taylor & Francis Inc.
