87343-26-8

Basic information

• Product Name: <<5-(benzyloxy)glutaryl>oxy>methyl penicillanate sulfone
• CAS NO: 87343-26-8
• Molecular Weight: 467.497
• Mol File: 87343-26-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: <<5-(benzyloxy)glutaryl>oxy>methyl penicillanate sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: <<5-(benzyloxy)glutaryl>oxy>methyl penicillanate sulfone(87343-26-8)
• EPA Substance Registry System: <<5-(benzyloxy)glutaryl>oxy>methyl penicillanate sulfone(87343-26-8)

Safety Data

• Hazardous Substances Data: 87343-26-8(Hazardous Substances Data)

Upstream product

• 76247-39-7 iodomethyl penicillanate 1,1-dioxide 
• 87353-15-9 tetrabutylammonium benzylglutarate 

Relevant articles and documents

Orally effective acid prodrugs of the β-lactamase inhibitor sulbactam

Sulbactam (1) is a β-lactamase inhibitor with limited oral bioavailability. Lipophilic double-ester prodrug sulbactam pivoxil (2) significantly improves the oral absorption of sulbactam, as does the mutual prodrug double ester sultamicillin (3). We have found that double-ester prodrugs of sulbactam terminating in a carboxyl group (8) also were effective oral-delivery vehicles in rats. Carboxyl-terminated double esters have several potential advantages over their nonionizable lipophilic counterparts, including water solubility, crystallinity, choice of salts for dosage forms, and formation of innocuous byproducts on hydrolysis.