873436-91-0 Usage
Uses
Trifluoroacetic Acid of PU-H71 is a potent Hsp90 inhibitor (IC50 = 50 nM). Hsp90 plays a critical role in modulating the activity of many cell signaling proteins and are an attractive target for anti-cancer therapeutics. Studies indicate that Hsp90 inhibitors may serve as potential anti-Parkinson′s disease.
Check Digit Verification of cas no
The CAS Registry Mumber 873436-91-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,3,4,3 and 6 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 873436-91:
(8*8)+(7*7)+(6*3)+(5*4)+(4*3)+(3*6)+(2*9)+(1*1)=200
200 % 10 = 0
So 873436-91-0 is a valid CAS Registry Number.
873436-91-0Relevant articles and documents
A facile and efficient synthesis of d6-labeled PU-H71, a purine-scaffold Hsp90 inhibitor
Taldone, Tony,Zatorska, Danuta,Kang, Yanlong,Chiosis, Gabriela
scheme or table, p. 47 - 49 (2010/04/06)
PU-H71 is a purine-scaffold Hsp90 inhibitor currently undergoing late stage preclinical evaluation for the treatment of cancer. In this investigation, we present a simple method for the synthesis of d6-labeled PU-H71 for use as an internal standard to accurately quantitate the drug in biological matrices based on an LC-MS-MS method. PU-H71-d6 was synthesized in five steps using readily available 1,3-dibromopropane-d6 and is an important compound for the advancement of our clinical program. Copyright
