873437-07-1 Usage
Purine derivative
The compound is derived from purine, which is a heterocyclic aromatic organic compound, indicating its potential role in biological processes and interactions with other molecules.
Fluorine atom at the 2-position
The presence of a fluorine atom at the 2-position suggests that the compound may exhibit unique chemical and biological properties, as fluorine is known to influence the reactivity and binding affinity of molecules.
Complex substituted phenyl group at the 8-position
The compound features a substituted phenyl group with iodine, methoxy, and methyl groups at the 2-, 4-, and 5-positions, respectively. This complex structure may contribute to its potential pharmacological activity and selectivity.
Pharmaceutical research interest
The compound is of interest in pharmaceutical research due to its potential as a drug candidate for various applications, indicating its potential for therapeutic use.
Biological activity
1H-Purin-6-amine, 2-fluoro-8-[(2-iodo-4,5-dimethoxyphenyl)methyl]may exhibit biological activity related to its structural features, suggesting that it could interact with biological targets and have an impact on biological processes.
Further investigation warranted
The unique molecular structure and potential pharmacological activity of the compound make it a valuable target for further research and development, indicating the need for additional studies to explore its therapeutic potential.
Medicinal chemistry field
The compound's structure and potential applications make it a relevant target for research and development in the field of medicinal chemistry, which focuses on the design, synthesis, and evaluation of small molecules for therapeutic use.
Check Digit Verification of cas no
The CAS Registry Mumber 873437-07-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,3,4,3 and 7 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 873437-07:
(8*8)+(7*7)+(6*3)+(5*4)+(4*3)+(3*7)+(2*0)+(1*7)=191
191 % 10 = 1
So 873437-07-1 is a valid CAS Registry Number.
873437-07-1Relevant academic research and scientific papers
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90
He, Huazhong,Zatorska, Danuta,Kim, Joungnam,Aguirre, Julia,Llauger, Laura,She, Yuhong,Wu, Nian,Immormino, Robert M.,Gewirth, Daniel T.,Chiosis, Gabriela
, p. 381 - 390 (2007/10/03)
Hsp90 is a chaperone protein that allows cancer cells to tolerate the many components of dysregulated pathways. Its inactivation may result in targeting multiple molecular alterations and, thus, in reverting the transformed phenotype. The PU-class, a purine-scaffold Hsp90 inhibitor series, has been reported to be potent and selective against Hsp90 both in vitro and in vivo models of cancer. Here, a series of this class was synthesized and evaluated as inhibitors of the chaperone. The structure-activity relationship and selectivity for tumor Hsp90 of compounds within the series is presented. The study identifies water soluble derivatives (> 5 mM in PBS pH 7.4) of nanomolar potency (IC50 ～ 50 nM) in cellular and animal models of cancer. Binding affinities of these compounds for Hsp90 correlate well with their biological activities. When administered in vivo to mice bearing MDA-MB-468 human breast cancer xenografted tumors, these agents result in pharmacologically relevant concentrations and, accordingly, in modulation of Hsp90-client proteins in tumors.
SMALL-MOLECULE HSP90 INHIBITORS
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Page/Page column 34, (2008/06/13)
Hsp90 inhibitors havin are rovided havin the formula: (I) with a 2',4',5'-substitution pattern on the right-side aryl moiety. X1 represents two substituents, which may be the same or different, disposed in the 4' and 5' positions on the aryl group, wherei
