873465-45-3Relevant academic research and scientific papers
Kynurenamines as neural nitric oxide synthase inhibitors
Entrena, Antonio,Camacho, M. Encarnación,Carrión, M. Dora,López-Cara, Luisa C.,Velasco, Guillermo,Léon, Josefa,Escames, Germaine,Acu?a-Castroviejo, Dario,Tapias, Víctor,Gallo, Miguel A.,Vivó, Antonio,Espinosa, Antonio
, p. 8174 - 8181 (2005)
To find new compounds with potential neuroprotective activity, we have designed, synthesized, and characterized a series of neural nitric oxide synthase (nNOS) inhibitors with a kynurenamine structure. Among them, N-[3-(2-amino-5-methoxyphenyl)-3-oxopropy
Development of urea and thiourea kynurenamine derivatives: Synthesis, molecular modeling, and biological evaluation as nitric oxide synthase inhibitors
Chayah, Mariem,Carri?n, M. Dora,Gallo, Miguel A.,Jiménez, Rosario,Duarte, Juan,Camacho, M. Encarnaci?n
, p. 874 - 882 (2015/05/05)
Herein we describe the synthesis of a new family of kynurenamine derivatives with a urea or thiourea moiety, together with their in vitro biological evaluation as inhibitors of both neuronal and inducible nitric oxide synthases (nNOS and iNOS, respectivel
