873551-76-9Relevant academic research and scientific papers
Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist
Ito, Satoru,Satoh, Atsushi,Nagatomi, Yasushi,Hirata, Yukari,Suzuki, Gentaroh,Kimura, Toshifumi,Satow, Akio,Maehara, Shunsuke,Hikichi, Hirohiko,Hata, Mikiko,Kawamoto, Hiroshi,Ohta, Hisashi
experimental part, p. 9817 - 9829 (2009/04/11)
We describe here the discovery and the structure-activity relationship (SAR) of a series of 4-(1-Aryltriazol-4-yl)-tetrahydropyridines as novel mGluR1 antagonists. Our extensive chemical modification of lead compound 2 successfully led to fluoropyridine a
