873556-36-6Relevant academic research and scientific papers
Rationally-designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis
Somu, Ravindranadh V.,Boshoff, Helena,Qiao, Chunhua,Bennett, Eric M.,Barry III, Clifton E.,Aldrich, Courtney C.
, p. 31 - 34 (2007/10/03)
A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC99 = 0.19 μM) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in
