873571-92-7Relevant academic research and scientific papers
2-thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action
Geronikaki,Eleftheriou,Vicini,Alam,Dixit,Saxena
, p. 5221 - 5228 (2008)
SHP-2, a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene, mediates cell signaling by growth factors and cytokines via the RAS/MAP kinase pathway. Somatic mutations in PTPN11 gene account for approximately 18% of juvenile myelomonocytic
