873659-40-6Relevant academic research and scientific papers
Farnesyltransferase Inhibitors Inhibit the Growth of Malaria Parasites In Vitro and In Vivo
Wiesner, Jochen,Kettler, Katja,Sakowski, Jacek,Ortmann, Regina,Katzin, Alejandro M.,Kimura, Emilia A.,Silber, Katrin,Klebe, Gerhard,Jomaa, Hassan,Schlitzer, Martin
, p. 251 - 254 (2004)
The inhibition of farnesyltransferase was recently suggested as a new strategy for malaria therapy. A class of farnesyltransferase inhibitors such as 1 has been prepared which have in vivo activity in a murine malaria model. These inhibitors significantly
Benzophenone-based farnesyltransferase inhibitors with high activity against Trypanosoma cruzi
Esteva, Monica I.,Kettler, Katja,Maidana, Cristina,Fichera, Laura,Ruiz, Andrés M.,Bontempi, Esteban J.,Andersson, Bj?rn,Dahse, Hans-Martin,Haebel, Peter,Ortmann, Regina,Klebe, Gerhard,Schlitzer, Martin
, p. 7186 - 7191 (2007/10/03)
Less toxic drugs are needed to combat the human parasite Trypanosoma cruzi (Chagas's disease). One novel target for antitrypanosomal drug design is farnesyltransferase. Several farnesyltransferase inhibitors based on the benzophenone scaffold were assayed
