87367-63-3

Upstream product

• 4549-31-9 1,7-dibromoheptane 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 87367-73-5 2-(4-{7-[4-(2,2-Bis-ethoxycarbonyl-vinyl)-phenoxy]-heptyloxy}-benzylidene)-malonic acid diethyl ester 
• 87367-82-6 2-(4-{7-[4-(1,2-Dicarboxy-ethyl)-phenoxy]-heptyloxy}-phenyl)-succinic acid 
• 87367-95-1 C₂₇H₃₀N₂O₆ 

Relevant academic research and scientific papers

Synthesis and mesomorphic properties of new methylene-linked linear symmetrical liquid crystal dimers

A series of methylene-linked symmetrical liquid crystal dimers were synthesized. Their structures were confirmed by physicochemical techniques. Differential scanning calorimetry and polarizing optical microscopy verified the liquid crystal behaviors and t

Biological evaluation of bisbenzaldehydes against four Mycobacterium species

A series of bisbenzaldehydes and structurally related analogs, conveniently synthesized via microwave-assisted reactions, were evaluated in vitro against drug susceptible and multi-drug resistant Mycobacterium tuberculosis, against virulent Mycobacterium bovis, against Mycobacterium ulcerans and against two Mycobacterium avium subspecies. Among the 33 substances that were tested, compound 12, i.e. 4,4′-[1,12-dodecanediyl(oxy)]bisbenzaldehyde, emerged as the most promising hit. Its activity was further confirmed in an intracellular growth inhibition assay of M. tb in murine J774 A.1 macrophages. None of the compounds showed significant cytotoxicity on human C3A hepatocytes in a neutral red dye uptake assay and no genotoxicity or mutagenicity was observed as demonstrated by a VITOTOX test and confirmed with a comet assay.

Bis(oxyphenylene)benzimidazoles: A novel class of anti-Plasmodium falciparum agents

A small library of 26 2,2′-[alkane-α,ω- diylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and evaluated against Giardia intestinalis, Entamoeba histolytica, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium

Novel bisbenzimidazoles with antileishmanial effectiveness

A small library of 2,2′-[(α,ω-alkanediylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and screened in vitro against Pneumocystis carinii, Trypanosoma brucei rhodesiense, and Leishmania donovani. Among the six tested compounds two derivatives e

Synthesis and thermal properties of twin dimers containing cyanostilbene groups as a mesogenic group

Twin dimers (TDs) with a different linking group (ester or ether) between the mesogenic group (cycmostilbene moiety) and the flexible spacer were synthesized to clarify the effect of the linking group on the mesomorphic properties. The sequence of the est

The syntheses of 4,4'-(1,n-dioxaalkane)-bisbenzaldehydes and 4,4'-(1,n- dioxaalkane)-bis(α-methoxy phenylacetic acids)

The syntheses of 4,4'-(1,n-dioxaalkane)-bis(α-methoxyphenylacetic acids) were conducted using a base-catalyzed reaction. The reactants were potassium hydroxide (or lithium hydroxide/lithium chloride), bromoform, methanol and 4,4'-(1,n-dioxaalkane)-bisbenz

Bisoxadiazolidine derivative

A bisoxadiazolidine dione derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, which is useful as an insulin sensitivity-increasing drug, and a pharmaceutical composition thereof. STR1 each represents a phenylene group L: (1) an oxygen, (2) a STR2 (3) a --S(O)n --, (4) a --CO--, (5) a STR3 (6) an alkylene group or an alkenylene group which may respectively be interrupted with an oxygen atom and/or a sulfur atom.

THERMOTROPIC COMPOUNDS WITH TWO TERMINAL MESOGENIC UNITS AND A CENTRAL SPACER. 5. HOMOLOGOUS SERIES OF POLYMETHYLENE-α, ω-BIS(P-OXYBENZYLIDENE ANILINE)

Two series of new thermotropic compounds with two terminal mesogenic units, p-oxybenzylidene-p-substituted anilines, attached to both ends of central polymethylene spacer were prepared.The first series of compounds has central polymethylene spacers of var

MESOGENIC POLYMERS. 6. TWO SERIES OF ISOMERIC POLYAZOMETHINES.

Two homologoous series of alternating rigid-flexible, main chain liquid crystalline polyimines are reported; one based on terephthaldehyde the other based on p-phenylenediamine. It was found through examination of optical microscopic, x-ray diffraction an