873685-00-8Relevant academic research and scientific papers
Synthesis, Characterization, and Catalytic Activity of Chiral NHC Platinum(II) Pyridine Dihalide Complexes
Blanc, Aurélien,De Frémont, Pierre,Hatey, Delphine,Pale, Patrick,Pertschi, Romain
supporting information, (2020/03/16)
A series of platinum(II) dihalide pyridine complexes bearing chiral C2-symmetric N-heterocyclic carbene (NHC) ligands [Pt(NHC*)(Py)(Hal)2] was synthesized in a one-pot procedure and characterized by NMR spectroscopy and single crystal X-ray diffraction (SC-XRD). The complexes were tested for the asymmetric cycloisomerization of enynol into bicyclo[3.1.0]hexanone and feature an excellent catalytic activity at room temperature along with a modest enantiomeric induction (up to 39% ee).
Enantioselective copper catalysed 1,4-conjugate addition reactions using chiral N-heterocyclic carbenes
Winn, Caroline L.,Guillen, Frédéric,Pytkowicz, Julien,Roland, Sylvain,Mangeney, Pierre,Alexakis, Alexandre
, p. 5672 - 5695 (2007/10/03)
The preparation of a variety of chiral N-heterocyclic carbene (NHC) precursors is described. The relative merits of imidazolinium salts and silver carbenes as NHC precursors are discussed with respect to their synthesis, stability and performance in the copper catalysed conjugate addition of dialkyl zinc reagents to a variety of Michael acceptors. Enantioselectivities of up to 93% were achieved using as little as 4% of chiral ligand.
