873693-47-1

Basic information

• Product Name: Benzo[b]thiophene-2-ethanaMine, N,N-diMethyl-3-[(1R)-1-(2-pyridinyl)ethyl]-
• Synonyms: Benzo[b]thiophene-2-ethanaMine, N,N-diMethyl-3-[(1R)-1-(2-pyridinyl)ethyl]-;N,N-dimethyl-2-[3-[(1R)-1-pyridin-2-ylethyl]-1-benzothiophen-2-yl]ethanamine
• CAS NO: 873693-47-1
• Molecular Formula: C19H22N2S
• Molecular Weight: 310.45638
• Mol File: 873693-47-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzo[b]thiophene-2-ethanaMine, N,N-diMethyl-3-[(1R)-1-(2-pyridinyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzo[b]thiophene-2-ethanaMine, N,N-diMethyl-3-[(1R)-1-(2-pyridinyl)ethyl]-(873693-47-1)
• EPA Substance Registry System: Benzo[b]thiophene-2-ethanaMine, N,N-diMethyl-3-[(1R)-1-(2-pyridinyl)ethyl]-(873693-47-1)

Safety Data

• Hazardous Substances Data: 873693-47-1(Hazardous Substances Data)

Upstream product

• 1035454-09-1 [2-(3-bromo-benzo[b]thiophen-2-yl)-ethyl]dimethyl-amine hydrobromide 
• 873692-91-2 [2-(3-bromo-benzo[b]thiophen-2-yl)-ethyl]dimethyl-amine 
• 873693-17-5 dimethyl-{2-[3-(1-pyridin-2-yl-vinyl)-benzo[b]thiophen-2-yl]-ethyl}-amine 
• 873693-14-2 dimethyl{2-[3-(1-(pyridin-2-yl)ethyl)benzo[b]thiophen-2-yl]ethyl}amine 

Relevant articles and documents

Application of [BoPhoz Rh] catalysts in the asymmetric hydrogenation of a pyridyl benzothiophene alkene

The asymmetric hydrogenation of a pyridyl benzothiophene alkene has been successfully accomplished using [BoPhoz Rh] catalysts. By tailoring the steric properties of the BoPhoz ligand, the ee of the product could be increased from just 12% to 90%. This research further expands the substrate scope of the conventional class of functionalized alkenes amenable to catalytic asymmetric hydrogenation.

Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia

Analogues of the known H1-antihistamine R-dimethindene were profiled as potential agents for the treatment of insomnia. Several highly selective compounds were efficacious in rodent sleep models. On the basis of overall profile, indene 1d and benzothiophene 2a had pharmacokinetic properties suitable for evaluation in night time dosing. Compound 2a did not show an in vivo cardiovascular effect from weak hERG channel inhibition.

Sleep inducing compounds and methods relating thereto

Compounds having the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts, esters and solvates thereof, wherein R1, R2, R3a, R3b, L1, L2 and n are as defined herein. Such compounds generally function as H1 receptor ligands, and thus have utility as sleep inducing agents. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.