87375-18-6Relevant academic research and scientific papers
Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof
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, (2008/06/13)
A process for the preparation of beta-lactamase inhibiting 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives. R- and S-1-(ethoxycarbonyloxy)ethyl 6-alpha-(aminomethyl)penicillanate 1,1-dioxide are specifically described.
Beta-lactamase inhibiting 6-(alkoxyamino-methyl) penicillanic acid 1,1-dioxide and derivatives
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, (2008/06/13)
6-alpha/beta-[(C1 -C4)Alkoxyaminomethyl and benzyloxyaminomethyl]penicillanic acid 1,1-dioxides, pharmaceutically acceptable salts thereof and conventional esters thereof hydrolyzable under physiological conditions, all of which are
Salts of 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide esters and beta-lactam antibiotics
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, (2008/06/13)
Salts of readily hydrolyzable esters of 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide and (a) prodrug forms of ampicillin and amoxicillin or (b) ampicillin and amoxicillin and a dibasic acid are readily absorbed following oral adminstration, and are
Process for debromination of dibromopenicillanic acid and derivatives
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, (2008/06/13)
A process for the debromination of 6-monobromo- and 6,6-dibromopenicillanic acid, and various derivatives thereof, by the action of a bisulfite salt. The debrominated compounds produced find various utilities, as beta-lactamase inhibitors useful in therapy in combination with known beta-lactam antibiotics, or as intermediates in the further synthesis of useful beta-lactam compounds.
6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-lactamase inhibitors
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, (2008/06/13)
beta-Lactamase inhibitors which are 6-alpha- and 6-beta(aminomethyl)pencillanic acid 1,1-dioxides which are substituted on amino nitrogen with benzyl, hydroxybenzyl, picolyl or phenethyl; pharmaceutically-acceptable salts thereof; conventional esters ther
6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
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, (2008/06/13)
Beta-lactamase inhibitors which are 6-alpha- and 6-beta-(aminomethyl) and (1-aminoethyl)pencillanic acid 1,1-dioxides; pharmaceutically-acceptable salts thereof; conventional esters thereof which are hydrolyzable in vivo; bis-methanediol esters thereof; o
