873780-47-3Relevant academic research and scientific papers
Human P2Y6 receptor: Molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference
Costanzi, Stefano,Joshi, Bhalchandra V.,Maddileti, Savitri,Mamedova, Liaman,Gonzalez-Moa, Maria J.,Marquez, Victor E.,Harden, T. Kendall,Jacobson, Kenneth A.
, p. 8108 - 8111 (2005)
Combining molecular dynamics (MD) in a hydrated phospholipid (DOPC) bilayer, a Monte Carlo search, and synthesis of locked nucleotide analogues, we discovered that the Southern conformation of the ribose is preferred for ligand recognition by the P2Y
