873805-95-9Relevant academic research and scientific papers
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP
Coleman, Paul J.,Schreier, John D.,Cox, Christopher D.,Fraley, Mark E.,Garbaccio, Robert M.,Buser, Carolyn A.,Walsh, Eileen S.,Hamilton, Kelly,Lobell, Robert B.,Rickert, Keith,Tao, Weikang,Diehl, Ronald E.,South, Vicki J.,Davide, Joseph P.,Kohl, Nancy E.,Yan, Youwei,Kuo, Lawrence,Prueksaritanont, Thomayant,Li, Chunze,Mahan, Elizabeth A.,Fernandez-Metzler, Carmen,Salata, Joseph J.,Hartman, George D.
, p. 5390 - 5395 (2008/04/03)
3,5-Diaryl-4,5-dihydropyrazoles were discovered to be potent KSP inhibitors with excellent in vivo potency. These enzyme inhibitors possess desirable physical properties that can be readily modified by incorporation of a weakly basic amine. Careful adjust
MITOTIC KINESIN INHIBITORS
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, (2008/06/13)
The present invention relates to fluorinated dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to
MITOTIC KINESIN INHIBITORS
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Page/Page column 42; 44, (2008/06/13)
The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to composition
PRODRUGS OF MITOTIC KINESIN INHIBITORS
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Page/Page column 52; 54, (2010/02/15)
The present invention relates to prodrugs of dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to
