873849-86-6

Basic information

• Product Name: bisMPA dendron
• Synonyms: Polyester bis-MPA dendron, 2 hydroxyl, 1 azide
• CAS NO: 873849-86-6
• Molecular Formula: C11H21N3O4
• Molecular Weight: 259.31
• Mol File: 873849-86-6.mol
• Article Data: 5

Chemical Properties

• Flash Point: >110℃
• Appearance: /
• Density: 1.120 g/mL at 25 °C
• Refractive Index: n20/D1.478
• Storage Temp.: ?20°C
• CAS DataBase Reference: bisMPA dendron(CAS DataBase Reference)
• NIST Chemistry Reference: bisMPA dendron(873849-86-6)
• EPA Substance Registry System: bisMPA dendron(873849-86-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 873849-86-6(Hazardous Substances Data)

Usage

Uses

Azide dendrons can be coupled to acetylene functionalized molecules, including acetylene dendrons to form asymmetric dendrimers.

General Description

calculated mol. wt. 259.3

Upstream product

• 2009-83-8 6-chloro-1-hexanol 
• 16837-14-2 2,2,5-trimethyl-1,3-dioxane-5-carboxylic acid 
• 4767-03-7 2,2-bis(hydroxymethyl)propionic acid 
• 408322-03-2 2,2,5-trimethyl-1,3-dioxane-5-carboxylic anhydride 
• 146292-90-2 6-azidohexan-1-ol 

Downstream Products

• 873849-89-9 C₄₁H₆₉N₃O₂₂ 
• 919988-18-4 (HO)4-[G₂]-N₃ 

Relevant articles and documents

Cationic poly(ester amide) dendrimers: Alluring materials for biomedical applications

Novel cationic poly(ester amide) dendrimers have been synthesized by copper(i) azide-alkyne cycloaddition (CuAAC) of a tripropargylamine core and azide-terminated dendrons, in turn prepared by iterative amide coupling of the new monomer 2,2′-bis(glycyloxymethyl)propionic acid (bis-GMPA). The alternation of ester and amide groups provided a dendritic scaffold that was totally biocompatible and degradable in aqueous media at physiological and acidic pH. The tripodal dendrimers naturally formed rounded aggregates with a drug that exhibited low water solubility, camptothecin, thus improving its cell viability and anti-Hepatitis C virus (anti-HCV) activity. The presence of numerous peripheral cationic groups enabled these dendrimers to form dendriplexes with both pDNA and siRNA and they showed effective in vitro siRNA transfection in tumoral and non-tumoral cell lines.

Method for making amphiphilic dendrimers

A series of AB-type amphiphilic dendritic polyesters have been prepared divergently, in which two hybrids were coupled via the copper(1)-catalyzed triazole formation.

Multivalent, bifunctional dendrimers prepared by click chemistry

Unsymmetrical dendrimers, containing both mannose binding units and coumarin fluorescent units, have been prepared using click chemistry and shown to be highly efficient, dual-purpose recognition/detection agents for the inhibition of hemagglutination. The Royal Society of Chemistry 2005.