873937-00-9

Upstream product

• 873936-98-2 Ro 4808591 
• 31600-86-9 2-methoxyphenyllithium 
• 892482-98-3 (2,6-dichloro-pyridin-3-yl)-(2-methoxy-phenyl)-methanol 

Downstream Products

• 892482-99-4 6-chloro-3-(2-methoxy-phenyl)-1H-pyrazolo[3,4-b]pyridine 
• 873937-01-0 (2-Amino-6-chloro-pyridin-3-yl)-(2-methoxy-phenyl)-methanone 

Relevant academic research and scientific papers

2,6-Diaminopyridine derivatives

Novel 2,6-diaminopyridine derivatives of formula wherein R1 and R2 are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 2,6-diaminopyridine derivatives.

PYRAZOLO-HETEROARYL COMPOUNDS USEFUL TO TREAT TNF-ALPHA AND IL-1 MEDIATED DISEASES

A compound of formula (I) wherein the groups R1-R4, X and Y are as defined in the specification, useful to treat TNF-Alpha and IL-1 mediated diseases.