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Usage

Uses

Used in Pharmaceutical Industry:
1-(6-CHLORO-PYRIDIN-2-YL)-PIPERAZINE is used as a building block for the synthesis of pharmaceutical compounds due to its ability to interact with biological targets and receptors, which is essential for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(6-CHLORO-PYRIDIN-2-YL)-PIPERAZINE is utilized as an intermediate in the creation of agrochemicals, contributing to the development of products that can enhance crop protection and management.
Used in Organic Synthesis:
1-(6-CHLORO-PYRIDIN-2-YL)-PIPERAZINE is employed as an organic intermediate for the synthesis of various organic compounds, broadening its applications across different chemical and research domains.
Used in Medicinal Chemistry and Drug Discovery:
1-(6-CHLORO-PYRIDIN-2-YL)-PIPERAZINE is used as a research tool in medicinal chemistry and drug discovery, where its interaction with biological targets can lead to the identification of new therapeutic agents and the advancement of understanding in molecular biology.

InChI:InChI=1/C9H12ClN3/c10-8-2-1-3-9(12-8)13-6-4-11-5-7-13/h1-3,11H,4-7H2

Upstream product

• 854159-19-6 1-(6-chloro-2-pyridyl)-4-tritylpiperazine 
• 110-85-0 piperazine 
• 2402-78-0 2,6-dichloropyridine 
• 584-08-7 potassium carbonate 
• 120-43-4 4-ethoxycarbonylpiperazine 
• 34803-66-2 1-(2-pyridyl)piperazine 
• 854159-11-8 1-(2-pyridyl)-4-tritylpiperazine 

Relevant academic research and scientific papers

Synthesis and bioactivity of aripiprazole derivatives

Ten aripirazole (CAS 129722-12-9) derivatives were prepared and examined for dopamine receptor antagonist activity. The structures of these newly synthesized compounds were confirmed by their elemental analyses and by IR, 1H-NMR and mass spectra. It was demonstrated that all the new compounds have dopamine receptor antagonist activity to a certain extent. Three compounds showed more potent activity than aripiprazole. ECV · Editio Cantor Verlag.

First selective lithiation of pyridylpiperazines: Straightforward access to potent pharmacophores

The three isomers of pyridylpiperazines have been lithiated for the first time. The use of a superbase, an aminoalkoxide containing lithiating agent overcomes the chelating influence of the basic piperazine nitrogens, so that selective mono lithiation occurred alpha to pyridine nitrogen. This methodology offers a new access to diverse potent pharmacophores not easily prepared by other routes.

1-indolyalkyl-4-(substituted-pyridinyl)piperazines

A series of 1,4-disubstituted piperazine derivatives comprised of indol-3-ylalkyl and substituted pyridin-2-yl substituent groups. These compounds are useful as antidepressant agents.

1,2,4-TRIAZOL-3-ONE ANTIDEPRESSANTS

Phenoxyalkyl substituted-1,2,4-triazolones having anti-depressant properties typified by 2-3-4-(3-chlorophenyl)-1-piperazinyl!propyl!-5-ethyl-4-(2-phenoxyethyl)-2H-1,2, 4-triazol-3(4H)-one are disclosed.

Piperazinylpyridines

Compounds of the formula: STR1 and their N-oxides and acid-addition salts are disclosed having pharmacological activity as anorexic agents.