87395-03-7

Basic information

• Product Name: 2-Naphthalenamine, 1,2,3,4-tetrahydro-8-[(1-phenyl-1H-tetrazol-5-yl)oxy]-N,N-dipropyl-, (R)-
• CAS NO: 87395-03-7
• Molecular Formula: C23H29N5O
• Molecular Weight: 391.516
• Mol File: 87395-03-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Naphthalenamine, 1,2,3,4-tetrahydro-8-[(1-phenyl-1H-tetrazol-5-yl)oxy]-N,N-dipropyl-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Naphthalenamine, 1,2,3,4-tetrahydro-8-[(1-phenyl-1H-tetrazol-5-yl)oxy]-N,N-dipropyl-, (R)-(87395-03-7)
• EPA Substance Registry System: 2-Naphthalenamine, 1,2,3,4-tetrahydro-8-[(1-phenyl-1H-tetrazol-5-yl)oxy]-N,N-dipropyl-, (R)-(87395-03-7)

Safety Data

• Hazardous Substances Data: 87395-03-7(Hazardous Substances Data)

Upstream product

• 119432-88-1 ((R)-8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine 
• 14210-25-4 5-Chloro-1-phenyltetrazole 
• 78095-19-9 (2R)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide 

Relevant articles and documents

8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytryptamine receptor agonists

A series of 2-(alkylamino)tetralins related to 8-hydroxy-2-(di-n-propylamino)tetralin (21) were prepared and tested as dopamine (DA) and 5-hydroxytryptamine (5-HT) receptor agonists. Several of the compounds were potent 5-HT agonists devoid of DA-mimetic effects. N-Ethyl or N-propyl substitution of 8-hydroxy-2-aminotetralin gave the most potent agonists. It was shown that the most potent compound, (+)-21, has the 2R configuration. 5,8-Dimethoxy-2-(di-n-propylamino)tetralin (31) was found to be a weak DA agonist devoid of 5-HT activity. The corresponding indan derivative, 4,7-dimethoxy-2-(di-n-propylamino)indan (39), has been reported to be active on both DA and 5-HT receptors. The 5-HT-stimulating properties of compounds 21 and 39 as compared to the incapability of compound 31 to activate the 5-HT receptor is tentatively explained by the assumed mode of binding of the compounds to the 5-HT receptor.