87402-79-7

Upstream product

• 95851-37-9 (+)-Kadsurenone 

Downstream Products

• 104870-58-8 Acetic acid (2S,3R,3aS)-5-allyl-2-(3,4-dimethoxy-phenyl)-3-methyl-6-oxo-2,3-dihydro-6H-benzofuran-3a-yl ester 
• 104832-99-7 Acetic acid (2S,3R,3aR)-5-allyl-2-(3,4-dimethoxy-phenyl)-3-methyl-6-oxo-2,3-dihydro-6H-benzofuran-3a-yl ester 

Relevant academic research and scientific papers

Structure-Activity Relationships of Kadsurenone Analogues

Kadsurenone, a specific receptor antagonist of platelet-activating factor (PAF), and its analogues were prepared from derivatives of cinnamyl alcohol and (allyloxy)phenol.Racemic kadsurenone, resolvable by a Chiralpak column at low temperatures, has an IC50 value of 2 * 10-7 M, which is about 50percent of the activity of the natural product (IC50 = 1 * 10-7 M).The structural specificity of kadsurenone was further demonstrated by the low PAF-receptor-blocking activities of denudatin B, mirandin A, desallylkadsurenone, and the 2-epimer of kadsurenone.

NEOLIGNANS FROM PIPER FUTOKADSURA

The structures of three new neolignans, kadsurenone, kadsurin A and kadsurin B, isolated from Piper futokadsura were determined by chemical and spectral analysis and X-ray diffraction study.Their biological activities are reported.Key Word Index - Piper f