87408-22-8

Upstream product

• 186581-53-3 diazomethane 
• 87408-21-7 (S)-1-Benzyl-4-(2-hydroxy-ethyl)-azetidin-2-one 
• 81703-94-8 methyl (2Z)-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate 
• 81703-93-7 methyl (2E)-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate 
• 87411-81-2 methyl (3R,4S)-3-butylamino-4,5-(isopropylidenedioxy)pentanoate 
• 100-46-9 benzylamine 
• 87408-20-6 (R)-1-Benzyl-4-vinyl-azetidin-2-one 
• 87408-19-3 Methanesulfonic acid (S)-1-((R)-1-benzyl-4-oxo-azetidin-2-yl)-2-methanesulfonyloxy-ethyl ester 
• 87408-17-1 (R)-1-Benzyl-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-azetidin-2-one 
• 87408-18-2 (R)-1-Benzyl-4-((S)-1,2-dihydroxy-ethyl)-azetidin-2-one 
• 66601-82-9 methyl (S)-4,5-dihydroxy-4,5-O-isopropylidene-2-pentenoate 

Relevant academic research and scientific papers

β-Aminoacid derivatives and process for production thereof

A compound represented by the formula STR1 wherein R1 represents a lower alkyl group, a phenyl group or a benzyl group, or the two R1 groups together represent a group of the formula --CH2 --n in which n is an integer of 4 to 7; R2 represents a hydrogen atom, an alkyl group, or a substituted or unsubstituted aralkyl group; and Z represents a hydrogen atom, a lower alkyl group or a substituted or unsubstituted benzyl group; and a process for production thereof. The compounds of this invention are useful as intermediates for the synthesis of various biologically active substances, such as various antibiotics, particularly β-lactam antibiotic derivatives, thienamycin, antibiotic PS-5 and their analogous substances.

ENANTIOSELECTIVE SYNTHESIS OF (R)- AND (S)-4--2-AZETIDINONES FROM D-GLYCERALDEHYDE ACETONIDE

(R)-N-Benzyl-4--2-azetidinone (10) and (S)-4--2-azetidinone (17) were enantioselectively synthesized from the benzylamino ester 3, which was prepared by the highly stereoselective 1,4-addition of benzylami