874114-34-8

Basic information

• Product Name: Pyrazinecarboxaldehyde, 6-chloro-
• Synonyms: Pyrazinecarboxaldehyde, 6-chloro-;6-Chloropyrazine-2-carbaldehyde;6-Chloropyrazine-2-carboxaldehyde;2-Pyrazinecarboxaldehyde, 6-chloro-;6-Chloro-pyrazinecarboxaldehyde
• CAS NO: 874114-34-8
• Molecular Formula: C5H3ClN2O
• Molecular Weight: 142.54312
• Mol File: 874114-34-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 215.4±35.0℃ (760 Torr)
• Flash Point: 84.1±25.9℃
• Appearance: /
• Density: 1.432±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -1.52±0.10(Predicted)
• CAS DataBase Reference: Pyrazinecarboxaldehyde, 6-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazinecarboxaldehyde, 6-chloro-(874114-34-8)
• EPA Substance Registry System: Pyrazinecarboxaldehyde, 6-chloro-(874114-34-8)

Safety Data

• Hazardous Substances Data: 874114-34-8(Hazardous Substances Data)

Usage

General Description

Pyrazinecarboxaldehyde, 6-chloro- is a chemical compound with the molecular formula C7H5ClN2O. It is a derivative of pyrazinecarboxaldehyde and contains a chlorine atom at the 6th position on the carbon ring. Pyrazinecarboxaldehyde, 6-chloro- is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has also been studied for its potential use in organic light-emitting diodes (OLEDs) and other electronic applications. Pyrazinecarboxaldehyde, 6-chloro- is a versatile building block in organic chemistry and has various industrial and research applications.

Upstream product

• 1240602-95-2 (6-chloropyrazin-2-yl)methanol 
• 23611-75-8 6-chloro-pyrazine-2-carboxylic acid methyl ester 
• 85661-24-1 2-(methoxycarbonyl)pyrazine 1-oxide 
• 6164-79-0 methyl pyrazine-2-carboxylate 
• 874114-31-5 2-chloro-6-(1,3-dithian-2-yl)pyrazine 

Downstream Products

• 1197237-46-9 1-(6-chloropyrazin-2-yl)ethanone 

Relevant articles and documents

NITROGEN HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparing the compounds, compositions comprising the compounds, and methods of using the compounds as inhibitors of receptor tyrosine kinases, in particular oncogenic mutants of ErbB-receptors e.g. in the treatment of cancer.

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

On the nucleophilic tele-substitution of dichloropyrazines by metallated dithianes

The reaction of dichloropyrazines with a dithiane anion gave isomers of the expected formylated chloropyrazines after deprotection with methyl iodide. A tele-substitution mechanism accounts for these observations and is supported by deuterium labelling studies.