87412-04-2

Upstream product

• 76-83-5 trityl chloride 
• 42776-78-3 2'-O-tosyladenosine 
• 98-59-9 p-toluenesulfonyl chloride 
• 42822-80-0 2',3'-O-(dibutylstannylene)adenosine 

Downstream Products

• 124040-46-6 N⁶-(4,4'-dimethoxytrityl)-9-(2-deoxy-3-O-mesyl-5-O-trityl-β-D-threo-pentofuranosyl)adenine 
• 124040-45-5 N⁶-(4,4'-dimethoxytrityl)-9-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)adenine 
• 124040-47-7 9-(2-deoxy-3-O-mesyl-5-O-trityl-β-D-threo-pentofuranosyl)adenine 
• 66503-50-2 9-<(3S)-azido-2,3-dideoxy-5-O-trityl-β-D-glycero-pentofuranosyl>adenine 
• 117654-61-2 9-(3'-C-methyl-5'-O-(triphenylmethyl)-2'-deoxy-β-D-xylofuranosyl)adenine 
• 87422-40-0 9-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)adenine 

Relevant academic research and scientific papers

SYNTHESIS OF 2'- AND 3'-AZIDO-2',3'-DIDEOXYADENOSINES. PREPARATIVE APPLICATIONS OF THE DEOXYGENATIVE-HYDRIDE SHIFT AND β-ELIMINATION REACTIONS OF O-SULFONYLATED ADENOSINES

2'-Azido-2',3'-dideoxyadenosine (9) has been synthesized from adenosine (1) in 6-8 steps.The key intermediate, N6,O5'-bis(4,4'-dimethoxytrityl)-9-(3-deoxy-β-D-threo-pentofuranosyl)adenine (6a), was prepared in a one-flask manner by t

Synthesis and conformation of 1-(3'-C-methyl-2'-deoxy-β-D-xylofuranosyl)uracil and 9-(3'-C'-methyl-2'-deoxy-β-D-xylofuranosyl)adenine; two novel sugar-methylated nucleoside analogues

The preparation and high-resolution 1H NMR conformational analysis of the two novel nucleoside analogues, 1-(3'-C-methyl-2'-deoxy-β-D-xylofuranosyl)uracil (compound 1) and 9-(3'-C-methyl-2'-deoxy-β-D-xylofuranosyl)adenine (compound 2), are described.Compounds 1 and 2show a pronounced preference for the north conformation of the sugar ring.The north conformation corresponds with a sterically favoured equatorial location of the methyl group.The C4'-C5' conformation in 1 and 2 is predominantly γt (trans orientation of O5' and C3').The configuration at C3' in 1 and 2 was corroborated via a one-dimensional NOE experiment.The structure of compound 1 (originally assigned as having the C3'-methyl group on the β-face of the furanosyl moiety) is revised on the basis of these data.