87414-25-3 Usage
Uses
Used in Biomarker Research:
Thymine glycol is used as a biomarker for oxidative stress in various biological systems. Its presence in DNA indicates exposure to reactive oxygen species or ionizing radiation, which can lead to DNA damage and potentially contribute to the development of diseases such as cancer.
Used in Cancer Research and Therapy:
Thymine glycol is employed in cancer research as a target for therapeutic intervention. Due to its role in mutagenesis and carcinogenesis, thymine glycol presents an opportunity for the development of drugs that can either repair the DNA damage it causes or inhibit its formation, thereby potentially reducing the risk of cancer development and progression.
Used in DNA Repair Mechanism Studies:
Thymine glycol is utilized in the study of DNA repair mechanisms. Understanding how cells recognize and repair thymine glycol lesions can provide insights into the cellular response to DNA damage and may lead to the development of novel strategies for enhancing DNA repair efficiency.
Used in Antioxidant Development:
Thymine glycol is used in the development of antioxidants and other protective agents. By studying the formation of thymine glycol in the presence of various antioxidants, researchers can identify compounds that effectively prevent or reduce the formation of this DNA-damaging lesion, potentially leading to new treatments for conditions associated with oxidative stress.
Check Digit Verification of cas no
The CAS Registry Mumber 87414-25-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,4,1 and 4 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 87414-25:
(7*8)+(6*7)+(5*4)+(4*1)+(3*4)+(2*2)+(1*5)=143
143 % 10 = 3
So 87414-25-3 is a valid CAS Registry Number.
87414-25-3Relevant academic research and scientific papers
Thiol Addition to Quinones: Model Reactions for the Inactivation of Thymidylate Synthase by 5-p-Benzoquinonyl-2'-deoxyuridine 5'-Phosphate
Vadnere, Madhavi K.,Maggiora, Linda,Mertes, Mathias P.
, p. 1714 - 1720 (2007/10/02)
The reaction of methyl mercaptoacetate (5) with phenyl-p-benzoquinone (6) or 5-p-benzoquinonyl-3',5'-di-O-acetyl-2'-deoxyuridine (10) resulted in the formation of the three possible adducts to the quinone rings of 6 and 10; an additional product in the re
5-p-Benzoquinonyl-2'-deoxyuridine-5'-phosphate: A possible mechanism-based inhibitor of thymidylate synthetase
Maggiora,Chang,Hasson,Bigge,Mertes
, p. 1028 - 1036 (2007/10/02)
The title compound (91), designed as a suicide inhibitor of thymidylate synthetase, can be prepared by silver(II) oxide oxidative demethylation of the corresponding dimethoxyphenyl derivative. Compound 1 shows time-dependent inactivation of thymidylate sy
