87414-26-4

Upstream product

• 87414-24-2 5-(2,5-dimethoxyphenyl)-3',5'-diacetyl-2'-deoxyuridine 
• 76756-32-6 5-(2,5-dimethoxyphenyl)-2'-deoxyuridine 
• 87414-24-2 5-(2,5-dimethoxyphenyl)-3',5'-di-O-acetyl-2'-deoxyuridine 
• 102830-56-8 5-(2,5-dihydroxyphenyl)-3',5'-di-O-acetyl-2'-deoxyuridine 

Downstream Products

• 102830-56-8 5-(2,5-dihydroxyphenyl)-3',5'-di-O-acetyl-2'-deoxyuridine 
• 102830-57-9 5-<6-<(carbomethoxymethyl)thio>-2,5-dihydroxyphenyl>-3',5'-di-O-acetyl-2'-deoxyuridine 
• 102830-55-7 5-<4-<(carbomethoxymethyl)thio>-2,5-dihydroxyphenyl>-3',5'-di-O-acetyl-2'-deoxyuridine 
• 102851-30-9 5-<3-<(carbomethoxymethyl)thio>-2,5-dihydroxyphenyl>-3',5'-di-O-acetyl-2'-deoxyuridine 

Relevant academic research and scientific papers

Thiol Addition to Quinones: Model Reactions for the Inactivation of Thymidylate Synthase by 5-p-Benzoquinonyl-2'-deoxyuridine 5'-Phosphate

The reaction of methyl mercaptoacetate (5) with phenyl-p-benzoquinone (6) or 5-p-benzoquinonyl-3',5'-di-O-acetyl-2'-deoxyuridine (10) resulted in the formation of the three possible adducts to the quinone rings of 6 and 10; an additional product in the re

5-p-Benzoquinonyl-2'-deoxyuridine-5'-phosphate: A possible mechanism-based inhibitor of thymidylate synthetase

The title compound (91), designed as a suicide inhibitor of thymidylate synthetase, can be prepared by silver(II) oxide oxidative demethylation of the corresponding dimethoxyphenyl derivative. Compound 1 shows time-dependent inactivation of thymidylate sy