874157-06-9Relevant academic research and scientific papers
Design, synthesis and structure-activity relationships of new phosphinate inhibitors of MurD
Strancar, Katja,Blanot, Didier,Gobec, Stanislav
, p. 343 - 348 (2007/10/03)
A series of new phosphinate compounds were designed and synthesized as inhibitors of the d-glutamic acid-adding enzyme (MurD) involved in peptidoglycan biosynthesis. They were tested against the MurD enzyme from Escherichia coli, allowing initial structure-activity relationships to be deduced. Two compounds had IC50 values near 100 μM and constitute a promising starting point for further development.
