Cas 874198-93-3,Carbamic acid, [5-[3-(1,1-dimethylethyl)phenyl]-4,5,6,7-tetrahydro-2H-indazol-5-yl]-, 1,1-dimethylethyl ester

874198-93-3

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Basic information

Product Name: Carbamic acid, [5-[3-(1,1-dimethylethyl)phenyl]-4,5,6,7-tetrahydro-2H-indazol-5-yl]-, 1,1-dimethylethyl ester
Synonyms:
CAS NO:874198-93-3
Molecular Formula: C22H31N3O2
Molecular Weight: 369.507
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: Carbamic acid, [5-[3-(1,1-dimethylethyl)phenyl]-4,5,6,7-tetrahydro-2H-indazol-5-yl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
NIST Chemistry Reference: Carbamic acid, [5-[3-(1,1-dimethylethyl)phenyl]-4,5,6,7-tetrahydro-2H-indazol-5-yl]-, 1,1-dimethylethyl ester(874198-93-3)
EPA Substance Registry System: Carbamic acid, [5-[3-(1,1-dimethylethyl)phenyl]-4,5,6,7-tetrahydro-2H-indazol-5-yl]-, 1,1-dimethylethyl ester(874198-93-3)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 874198-93-3(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 874198-93-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,1,9 and 8 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 874198-93:
(8*8)+(7*7)+(6*4)+(5*1)+(4*9)+(3*8)+(2*9)+(1*3)=223
223 % 10 = 3
So 874198-93-3 is a valid CAS Registry Number.

874198-93-3Upstream product

1071976-58-3 C₂₄H₃₆N₂O₃

874198-93-3Downstream Products

874198-94-4 5-(3-tert-butyl-phenyl)-4,5,6,7-tetrahydro-2H-indazol-5-ylamine

874198-93-3Relevant academic research and scientific papers

Design and synthesis of cell potent BACE-1 inhibitors: Structure-activity relationship of P1′ substituents

Sealy, Jennifer M.,Truong, Anh P.,Tso, Luke,Probst, Gary D.,Aquino, Jose,Hom, Roy K.,Jagodzinska, Barbara M.,Dressen, Darren,Wone, David W.G.,Brogley, Louis,John, Varghese,Tung, Jay S.,Pleiss, Michael A.,Tucker, John A.,Konradi, Andrei W.,Dappen, Michael S.,Toth, Gergely,Pan, Hu,Ruslim, Lany,Miller, Jim,Bova, Michael P.,Sinha, Sukanto,Quinn, Kevin P.,Sauer, John-Michael

scheme or table, p. 6386 - 6391 (2010/06/11)

Using structure-guided design, hydroxyethylamine BACE-1 inhibitors were optimized to nanomolar Aβ cellular inhibition with selectivity against cathepsin-D. X-ray crystallography illuminated the S1′ residues critical to this effort, which culminated in compounds 56 and 57 that exhibited potency and selectivity but poor permeability and high P-gp efflux.

OXIME DERIVATIVE SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS

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Page/Page column 118-119, (2008/06/13)

The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a colletion of diseases, disorders, and conditions associated with abnormal deposition of A-beta protei

OXIME DERIVATIVE HYDROXYETHYLAMINE ASPARTYL-PROTEASE INHIBITORS

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Page/Page column 97-98; 125, (2010/02/15)

The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

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