874204-76-9Relevant academic research and scientific papers
Discovery of nonpeptidic small-molecule AP-1 inhibitors: Lead hopping based on a three-dimensional pharmacophore model
Tsuchida, Keiichi,Chaki, Hisaaki,Takakura, Tadakazu,Kotsubo, Hironori,Tanaka, Tadashi,Aikawa, Yukihiko,Shiozawa, Shunichi,Hirono, Shuichi
, p. 80 - 91 (2007/10/03)
We designed and synthesized small-molecule activator protein-1 (AP-1) inhibitors based on a three-dimensional (3D) pharmacophore model that we had previously derived from a cyclic decapeptide exhibiting AP-1 inhibitory activity. New AP-1 inhibitors with a
