874208-84-1

Basic information

• Product Name: m-PEG4-(CH2)3-acid
• Synonyms: m-PEG4-(CH2)3-acid
• CAS NO: 874208-84-1
• Molecular Formula: C11H22O6
• Molecular Weight: 250.28878
• Mol File: 874208-84-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: m-PEG4-(CH2)3-acid(CAS DataBase Reference)
• NIST Chemistry Reference: m-PEG4-(CH2)3-acid(874208-84-1)
• EPA Substance Registry System: m-PEG4-(CH2)3-acid(874208-84-1)

Safety Data

• Hazardous Substances Data: 874208-84-1(Hazardous Substances Data)

Usage

Description

m-PEG4-(CH2)3-acid is a PEG (polyethylene glycol) linker that features a terminal carboxylic acid group. This terminal carboxylic acid is capable of reacting with primary amine groups in the presence of coupling agents such as EDC (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide) or HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate) to form a stable amide bond. The hydrophilic PEG spacer within the molecule enhances its solubility in aqueous environments, making it a versatile component in various applications.

Uses

Used in Bioconjugation:
m-PEG4-(CH2)3-acid is used as a bioconjugation agent for attaching biologically active molecules to other entities, such as nanoparticles or other biomolecules. The reason for its use in this application is the ability of the terminal carboxylic acid to form stable amide bonds with primary amine groups, facilitating the attachment process.
Used in Drug Delivery Systems:
In the pharmaceutical industry, m-PEG4-(CH2)3-acid is used as a component in drug delivery systems to improve the solubility and stability of therapeutic agents. The hydrophilic PEG spacer aids in the dispersion of hydrophobic drugs in aqueous environments, enhancing their bioavailability and therapeutic efficacy.
Used in Cosmetics and Personal Care:
m-PEG4-(CH2)3-acid is utilized as a solubility enhancer in cosmetics and personal care products. Its hydrophilic nature allows it to improve the solubility of various ingredients, ensuring even distribution and effectiveness of the product.
Used in Diagnostic Imaging:
In the field of diagnostic imaging, m-PEG4-(CH2)3-acid is used as a component in the development of contrast agents. The PEG linker can be attached to imaging agents to improve their solubility and circulation time in the body, leading to better imaging results.
Used in Biomedical Research:
m-PEG4-(CH2)3-acid is employed as a tool in biomedical research for the creation of biocompatible materials and the study of molecular interactions. The ability to form stable amide bonds with primary amines makes it a valuable component in the design of novel biomaterials and the investigation of biological processes.