87421-55-4Relevant academic research and scientific papers
Chiral separation of basic compounds on sulfated β-cyclodextrin-coated zirconia monolith by capillary electrochromatography
Hong, Jong-Seong,Park, Jung Hag
, p. 1809 - 1813 (2013/07/26)
Sulfated β-cyclodextrin (SCD)-coated zirconia monolith was used as the chiral stationary phase in capillary electrochromatography for enantiomeric separation of basic chiral compounds. SCD adsorbed on the zirconia surface provided a stable chiral stationary phase in reversed-phase eluents. Retention, chiral selectivity and resolution of a set of six basic chiral compounds were measured in eluents of varying pH, composition of methanol and buffer. Optimum mobile phase condition for the separation of the compounds was found to be methanol content of 30%, buffer concentration of 30 mM and pH of 4.0.
Parasympatholytic (Anticholinergic) Esters of the Isomeric 2-Tropanols. 2. Non-Glycolates
Atkinson, Edward R.,McRitchie-Ticknor, Donna D.,Harris, Louis S.,Archer, Sydney,Aceto, Mario D.,et al.
, p. 1772 - 1775 (2007/10/02)
The 19 esters in Table I were prepared from (+)-2α-tropanol, (-)-2β-tropanol, (+/-)-3-quinuclidinol, and a variety of non-glycolic acids in order to compare their central and pheripheral activities with those of the glycolates reported in the previous paper.The results (Table II) showed that esters 6 and 17 were approximately equivalent to one another and the atropine, that 8 was equal in both central and peripheral activity to reference glycolates, that 9 and 19 were less active than 8 but 9 had a substantially reduced central activity, and that 10 and 11 weremore active than the methoxy analogue reported earlier.
