87427-57-4

Usage

Uses

Used in Organic Synthesis:
Ethanone, 2-bromo-1-(4-bromo-3-chlorophenyl)is employed as a building block in organic synthesis for creating other chemical compounds. Its unique structure allows it to be a valuable intermediate in the synthesis of various organic molecules.
Used in Pharmaceutical Research:
Ethanone, 2-bromo-1-(4-bromo-3-chlorophenyl)is also used in pharmaceutical research as a key component in the development of new drugs. Its specific functional groups and structural features make it a promising candidate for the creation of novel pharmaceutical agents.
Used as a Reagent in Chemical Reactions:
Ethanone, 2-bromo-1-(4-bromo-3-chlorophenyl)serves as a reagent in various chemical reactions, facilitating the formation of desired products and aiding in the advancement of chemical processes.
Important in the Development of New Materials:
Ethanone, 2-bromo-1-(4-bromo-3-chlorophenyl)plays a significant role in the development of new materials, leveraging its unique properties to contribute to the creation of innovative substances with potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Ethanone, 2-bromo-1-(4-bromo-3-chlorophenyl)is used as a building block for the synthesis of new drugs, contributing to the development of novel therapeutic agents.
It is crucial to handle Ethanone, 2-bromo-1-(4-bromo-3-chlorophenyl)with care, as it may present potential hazards, and should be used in a controlled laboratory setting to ensure safety and proper utilization.

Upstream product

• 3114-31-6 1-(4-bromo-3-chlorophenyl)ethan-1-one 
• 1235711-34-8 4-bromo-3-chloro-N-methoxy-N-methyl-benzamide 
• 25118-59-6 4-bromo-3-chlorobenzoic acid 
• 21900-32-3 4-bromo-3-chlorobenzoyl chloride 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 1460223-04-4 1-(4-bromo-3-chlorophenyl)-2-imidazol-1-ylethanone 

Relevant academic research and scientific papers

2-ACYLAMINOTHIAZOLES FOR THE TREATMENT OF CANCER

The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) are useful in the preparation of a medicament, in particular for the treatment of cancer.

ACETYLENIC MICROBIOCIDES

Compounds of formula (I), wherein the other substituents HetAr, A', R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in claim 1, and their use in compositions and methods for the control and/or prevention of microbial infection, particularly fungal infection, in plants and to processes for the preparation of these compounds.

HETEROCYCLIC AMINE DERIVATIVES

The present invention relates to compounds of formula I wherein A, B, X, Y, Ar, R1, R2, R′, m and n are as defined herein and to pharmaceutical active acid addition salts thereof. Compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The compounds can be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

HETEROCYCLIC AMINE DERIVATIVES

The present invention relates to compounds of formula (I) wherein R1 is hydrogen, lower alkyl, halogen, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen, cyano, nitro, C3-6-cycloalkyl, -CH2-C3-6-cycloalkyl, -O-CH2-C3-6-cycloalkyl, -O-(CH2)2-O-lower alkyl, S(O)2CH3, SF5, -C(O)NH-lower alkyl, phenyl, -O-pyrimidinyl, optionally substituted by lower alkoxy substituted by halogen, or is benzyl, oxetanyl or furanyl; m Ar is aryl or heteroaryl, selected from the group consisting of phenyl, naphthyl, pyrimidinyl, pyridinyl, benzothiazolyl, quinolinyl, quinazolinyl, benzo[d][1.3]dioxolyl, 5,6,7,8- tetrahydro-quinazolinyl, pyrazolyl, pyrazinyl, pyridazinyl, or 1,3,4-oxadiazolyl; Y is a bond, -CH2-, -CH2CH2-, -CH(CF3)- or -CH(CH3)-; R2 is hydrogen or lower alkyl; A is CR or N; and R is hydrogen, cyano, halogen or lower alkyl; R' is hydrogen or halogen; with the proviso that when R' is halogen, then A is CH; B is CH or N; n is 0, 1 or 2; X is a bond, -CH2- or -O-; pharmaceutical active acid addition salts thereof. It has now been found that the compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The compounds may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH

The present invention is directed to certain imidazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and t