874285-13-9Relevant academic research and scientific papers
Identification of hydroxybenzoic acids as selective lactate receptor (GPR81) agonists with antilipolytic effects
Dvorak, Curt A.,Liu, Changlu,Shelton, Jonathan,Kuei, Chester,Sutton, Steven W.,Lovenberg, Timothy W.,Carruthers, Nicholas I.
supporting information, p. 637 - 639 (2012/11/07)
Following the characterization of the lactate receptor (GPR81), a focused screening effort afforded 3-hydroxybenzoic acid 1 as a weak agonist of both GPR81 and GPR109a (niacin receptor). An examination of structurally similar arylhydroxy acids led to the identification of 3-chloro-5-hydroxybenzoic acid 2, a selective GPR81 agonist that exhibited favorable in vivo effects on lipolysis in a mouse model of obesity.
