874301-22-1

Basic information

• Product Name: 1H-Benzimidazole-5-carboxamide, 2-(4-hydroxyphenyl)-N-methoxy-N-methyl-
• CAS NO: 874301-22-1
• Molecular Formula: C16H15N3O3
• Molecular Weight: 297.313
• Mol File: 874301-22-1.mol

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazole-5-carboxamide, 2-(4-hydroxyphenyl)-N-methoxy-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-5-carboxamide, 2-(4-hydroxyphenyl)-N-methoxy-N-methyl-(874301-22-1)
• EPA Substance Registry System: 1H-Benzimidazole-5-carboxamide, 2-(4-hydroxyphenyl)-N-methoxy-N-methyl-(874301-22-1)

Safety Data

• Hazardous Substances Data: 874301-22-1(Hazardous Substances Data)

Upstream product

• 391903-19-8 N-methoxy N-methyl 3,4-dinitrobenzoic acid amide 
• 24376-18-9 3,4-dinitrobenzoyl chloride 
• 528-45-0 3,4-dinitrobenzoic acid 
• 123-08-0 4-hydroxy-benzaldehyde 
• 660432-02-0 N-methoxy N-methyl 3,4-diaminobenzoic acid amide 

Downstream Products

• 129012-05-1 2-(4-hydroxyphenyl)-3H-benzoimidazole-5-carbaldehyde 
• 1612254-46-2 5-(4-propylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole 
• 874301-27-6 [2-(2-{2-[2-(2-{[2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carbonyl]-amino}-ethoxy)-ethoxy]-acetylamino}-ethoxy)-ethoxy]-acetic acid 
• 874301-25-4 2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carboxylic acid methyl ester 
• 874301-24-3 2'-(4-hydroxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzoimidazoyl-4-carboxylic acid 

Relevant articles and documents

Synthesis and investigation of novel benzimidazole derivatives as antifungal agents

The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal strains have resulted in an increase in demand for new antifungal agents. Various heterocyclic scaffolds with different mechanisms of action against fungi have been investigated in the past. Herein, we report the synthesis and antifungal activities of 18 alkylated mono-, bis-, and trisbenzimidazole derivatives, their toxicities against mammalian cells, as well as their ability to induce reactive oxygen species (ROS) in yeast cells. Many of our bisbenzimidazole compounds exhibited moderate to excellent antifungal activities against all tested fungal strains, with MIC values ranging from 15.6 to 0.975?μg/mL. The fungal activity profiles of our bisbenzimidazoles were found to be dependent on alkyl chain length. Our most potent compounds were found to display equal or superior antifungal activity when compared to the currently used agents amphotericin B, fluconazole, itraconazole, posaconazole, and voriconazole against many of the strains tested.

Design of new bidentate ligands constructed of two Hoechst 33258 units for discrimination of the length of two A3T3 binding motifs

The aim of this study is to develop bidentate minor-groove binders that bind the double binding motifs cooperatively. The new bidentate ligands (1) have been designed by connecting two Hoechst 33258 units with a polyether linker for cooperative binding wi