87432-81-3 Usage
Chemical structure
A fluorinated alcohol with a pyridine ring and a tert-butyl group attached
Target
Transient receptor potential ankyrin 1 (TRPA1) ion channel
Mechanism of action
Potent and selective antagonist of TRPA1
Research use
Study the role of TRPA1 in pain and inflammation
Pain response inhibition
Effectively inhibits TRPA1-mediated pain responses in animal models
Potential therapeutic applications
Development of new analgesic drugs, treatment of asthma, COPD, and other respiratory disorders
Pathophysiological relevance
Targeting TRPA1-related conditions
Potency
Potent antagonist of TRPA1
Selectivity
Selective for TRPA1 over other ion channels
Molecular weight
374.28 g/mol
Physical state
Unknown, likely a solid based on structure
Solubility
Unknown, may be soluble in organic solvents
Stability
Unknown, may be stable under certain conditions
Toxicity
Unknown, may have potential side effects or adverse reactions
Metabolism
Unknown, may be metabolized by certain enzymes or excreted unchanged
Pharmacokinetics
Unknown, may have specific absorption, distribution, metabolism, and excretion properties.
Check Digit Verification of cas no
The CAS Registry Mumber 87432-81-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,4,3 and 2 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 87432-81:
(7*8)+(6*7)+(5*4)+(4*3)+(3*2)+(2*8)+(1*1)=153
153 % 10 = 3
So 87432-81-3 is a valid CAS Registry Number.
87432-81-3Relevant articles and documents
Direct, Regiospecific 2-Lithiation of Pyridines and Pyridine 1-Oxides with in Situ Electrophilic Trapping
Taylor, Stephen L.,Lee, David Y.,Martin, J. C.
, p. 4156 - 4158 (2007/10/02)
Efficient synthetic routes to 2-substituted pyridines and 2,6-disubstituted pyridine 1-oxides involving direct lithiation with the sterically hindered base lithium 2,2,6,6-tetramethylpiperidide (LiTMP) in the presence of electrophiles that are compatible with the base, e.g., trimethylsilyl chloride (Me3SiCl) and hexafluoroacetone (HFA), are described.
