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• 6232-88-8 4-bromomethylbenzoic Acid 
• 771-61-9 2,3,4,5,6-pentafluorophenol 

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• 1166985-87-0 [C₃H₃N₂(CH₃)CH₂C₆H₄CO₂C₆F₅]⁽¹⁺⁾*Br^(1-)=[C₃H₃N₂(CH₃)CH₂C₆H₄CO₂C₆F₅]Br 

Relevant academic research and scientific papers

RADIOACTIVE RHODIUM COMPLEXES, PREPARATION METHODS AND USES THEREOF

The present invention concerns radioactive rhodium complexes, their preparation methods, and their use for the radiolabelling of biomolecules, especially monoclonal antibodies.

The synthesis of ruthenium and rhodium complexes with functionalized N-heterocyclic carbenes and their use in solid phase peptide synthesis

While N-heterocyclic carbenes (NHCs) are ubiquitous ligands in catalysts for organic or industrial synthesis, their potential to form stable transition metal complexes has hardly been exploited in metal bioconjugates. In this work, we describe a straightforward synthesis of carboxylato-functionalized imidazolium salts for covalent binding to peptides. Carbene complexes of Ru and Rh were prepared from these imidazolium salts using Ag2O, followed by transmetallation. The neuropeptide [Leu5]-enkephalin (Tyr-Gly-Gly-Phe-Leu) was chosen as a model peptide. Exploratory NMR experiments identified the Ru(p-cymene)Cl2 complex of the asymmetrically substituted imidazol-2-ylidene 3b as the most suitable metal carbene precursor for solid phase peptide synthesis (SPPS). After optimization of the conditions for SPPS, a ruthenium-NHC pseudoenkephalin (dichloro(η6-p-cymene) -[1-methyl-3-(methyl-p-benzoyl-Gly-Gly-Phe-Leu-OH)imidazol-2-ylidene] ruthenium(II), 12) was synthesized from 3b on solid phase using the 2-Cl-Trt resin and cleavage by 2% TFA to yield the free carboxylic acid. Peptide 12 was fully characterized by HPLC, 1H and 13C NMR and ESI-MS. Characteristic NMR signals, as well as the isotope pattern of Ru in the ESI-MS, unequivocally confirm the formation of this metalcarbene peptide bioconjugate. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

NITROOXY SARTAN DERIVATIVES AS ANGIOTENSIN II RECEPTOR BLOCKERS FOR THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES

Angiotensin II receptor blockers nitroderivatives of Formula (I) having wider pharmacological activity and enhanced tolerability. They can be employed for treatment cardiovascular and renal diseases and inflammatory processes.

PROCESS FOR PREPARING NITROOXY ESTERS, NITROOXY THIOESTERS, NITROOXY CARBONATES AND NITROOXY THIOCARBONATES, INTERMEDIATES USEFUL IN SAID PROCESS AND PREPARATION THEREOF

The present invention relates to a process for preparing nitrooxy esters, nitrooxy thioesters, nitrooxy carbonates and nitrooxy thiocarbonates of compounds having at least a hydroxyl or thiol functional group, according to the following reaction scheme, (