874450-44-9

Basic information

• Product Name: SEN 12333
• Synonyms: SEN 12333;4-MorpholinepentanaMide, N-[4-(3-pyridinyl)phenyl]-;N-[4-(3-Pyridinyl)phenyl]-4-MorpholinepentanaMide;WAY 317538;SEN 12333 WAY-317538
• CAS NO: 874450-44-9
• Molecular Formula: C20H25N3O2
• Molecular Weight: 339.4314
• Product Categories: Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 874450-44-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: SEN 12333(CAS DataBase Reference)
• NIST Chemistry Reference: SEN 12333(874450-44-9)
• EPA Substance Registry System: SEN 12333(874450-44-9)

Safety Data

• Hazardous Substances Data: 874450-44-9(Hazardous Substances Data)

Usage

Description

SEN 12333 is a nicotinic acetylcholine receptor (nAChR) agonist with neuroprotective properties. It exhibits functional antagonism at histamine H3 receptors and weak agonist activity at human ganglionic α3 nAChRs. SEN 12333 is both brain penetrant and orally bioavailable, making it a promising candidate for various applications in the medical field.

Uses

Used in Pharmaceutical Industry:
SEN 12333 is used as a neuroprotective agent for its ability to protect against cholinergic degeneration in rodent models. Its action as an nAChR agonist and histamine H3 receptor antagonist may contribute to its therapeutic potential in treating neurological disorders.
Used in Drug Development:
Due to its brain penetrance and oral bioavailability, SEN 12333 is used as a lead compound in the development of new drugs targeting the nicotinic acetylcholine receptors and histamine H3 receptors. This dual action may offer novel treatment strategies for a range of conditions, including neurodegenerative diseases and cognitive disorders.