874460-46-5 Usage
Uses
Used in Pharmaceutical Industry:
Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-phenyl-, hydrochloride, (2R,3S)is used as an impurity in Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-phenyl-, hydrochloride, (2R,3S)plays a significant role in the development and quality control of Aprepitant, ensuring the purity and efficacy of the drug.
As an Antiemetic Agent:
Aprepitant, which contains Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-phenyl-, hydrochloride, (2R,3S)as an impurity, is used as an antiemetic agent. It helps in preventing nausea and vomiting, particularly in patients undergoing chemotherapy or radiotherapy treatments. Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-phenyl-, hydrochloride, (2R,3S)-'s presence in Aprepitant contributes to its overall effectiveness in managing emesis.
In Drug Metabolism Studies:
Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-phenyl-, hydrochloride, (2R,3S)is relevant in understanding the metabolism of Aprepitant. In vitro studies using human liver microsomes have shown that Aprepitant is primarily metabolized by the CYP3A4 enzyme, with minor metabolism by CYP1A2 and CYP2C19. The absence of metabolism by other enzymes like CYP2D6, CYP2C9, or CYP2E1 highlights the compound's selectivity and potential for reduced drug-drug interactions.
Check Digit Verification of cas no
The CAS Registry Mumber 874460-46-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,4,6 and 0 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 874460-46:
(8*8)+(7*7)+(6*4)+(5*4)+(4*6)+(3*0)+(2*4)+(1*6)=195
195 % 10 = 5
So 874460-46-5 is a valid CAS Registry Number.
