87461-00-5Relevant academic research and scientific papers
Reactions with Aziridines (Aziranes), 29. N-Acylated or N-Sulfonated Esters of 2-Aminoethylphosphonic Acid by Mean of Base Catalyzed Aminoethylation of Diesters of Phosphoric Acid with Activated Aziridines.
Stamm, Helmut,Gerster, Gerhard,Baumann, Thomas
, p. 2936 - 2957 (2007/10/02)
The sodium salts 2 of diesters of phosphoric acid 1 are amidoethylated at phosphorus with N-acylaziridines 3 or N-sulfonylaziridines 13 under proper reaction conditions at room temperature.In this manner a broad variation of N-acylated or N-sulfonated esters of 2-aminoethylphosphonic acids (5a-u, 15a-i) are obtained, mostly in good yields. 2-Methylated 2-aminoethylphosphonic esters are formed selectively in two cases by reaction of 2-methylated activated aziridines.
