87462-65-5Relevant academic research and scientific papers
The Effect of Two-dimensional Ordering on Photoreactions of Long-chain Unsaturated Carboxylic Acids
Guo, Bo Zhang,Tripathi, Sadhana,Taylor, D. Martin,Stirling, Charles J. M.
, p. 479 - 481 (2007/10/02)
Long chain alkanoic acids with terminal alkenyl and alkynyl groups are subjected to UV irradiation in ordered (Langmuir-Blodgett) and disordered films; polymerisation occurs in the LB films but only dissociation and desorption in the disordered films.
NEW RADIOHALOGENATED ALKENYL TELLURIUM FATTY ACIDS
Srivastava, Prem C.,Knapp, Furn F.,Kabalka, George W.
, p. 49 - 58 (2007/10/02)
Radiolabeled long-chain fatty acids have diagnostic value as radiopharmaceutical tools in myocardial imaging.Some applications of these fatty acids are limited due to their natural metabolic degradation in vivo with subsequent washout of the radioactivity
Effect of Tellurium Position on the Myocardial Uptake of Radioiodinated 18-Iodotellura-17-octadecenoic Acid Analogues
Knapp, F.F.,Srivastava, P.C.,Callahan, A.P.,Cunningham, E.B.,Kabalka, G.W.,Sastry, K.A.R.
, p. 57 - 63 (2007/10/02)
The effect of tellurium (Te) position on myocardial specifity and retention of fatty acids in which radioiodide is stabilized as a trans-(E)-vinyl iodode has been evaluated in rats.Five analogues of 18-iodo-17-octadecenoic acid (ICH=CH-R-Te-R'-COOH) with Te at positions 5,7,9,11, and 13 were prepared by coupling of a trans-diiodoalkene (ICH=CH-R-I) with the requisite sodium telluride substrate (NaTe-R'-COOR''; R''=Me or Et), followed by basic hydrolysis.By varying R and R', a series of analogues with a chain length of 18 carbon atoms was prepared.T he telluride substrates were generated in situ by NaBH4 reduction of the corresponding ditellurides, and the diiodoalkenes were prepared by sodium iodide-chloramine-T treatment of the corresponding vinylboronic acids .The vinylboronic acids were prepared by treatment of the terminal acetylenes (HCC-R-I), synthesized from commercially available materials, with catecholborane.All new compounds were analyzed by TLC, NMR, MS, and elemental analyses.The 125I analogues were prepared in the same manner and evaluated in rats (four per group).Heart uptake and retention were dependent upon the Te position.The analogue with Te at position 5 showed the most pronounced (5-min values) heart uptake (3.7-4.1 dose/g), myocardial retention, and heart/blood ratios (37:1) and is a candidate for radiolabeling with 123I and further evaluation as a myocardial imaging agent.
