874646-10-3Relevant academic research and scientific papers
Total synthesis and determination of the absolute stereochemistry of the squalene synthase inhibitors CJ-13,981 and CJ-13,982
Calo, Frederick,Bondke, Alexander,Richardson, Jeffery,White, Andrew J.P.,Barrett, Anthony G.M.
supporting information; experimental part, p. 3388 - 3390 (2009/09/05)
The absolute and relative stereochemistries of the potent squalene synthase inhibitors CJ-13,981 and CJ-13,982 were determined to be 3S,4S by total synthesis of their antipodes using, as a key step, the diastereoselective alkylation of a chiral dioxolanon
N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF
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Page/Page column 79, (2008/06/13)
The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof, in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.
