874663-39-5Relevant academic research and scientific papers
2-Amino-4-pyrrolidinothieno[2,3-d]pyrimidine-6-carboxylic acid as an N-terminal surrogate in amino acid and peptide analogues
Bissyris, Evangelos E.,Belekos, Dimitris,Magafa, Vassiliki,Tsoungas, Petros G.,Varvounis, George,Cordopatis, Paul
, p. 3159 - 3166 (2005)
2-Amino-4-pyrrolidinothieno[2,3-d]pyrimidine-6-carboxylic acid (4) (ATPC) is an unnatural amino acid with promise in applications as a building block for the synthesis of peptidomimetics. ATPC was obtained from both 3a and 3b thienopyrimidines by hydrolysis and hydrogenolysis, respectively. The synthesis of eleven ATPC-amino acids and two ATPC-peptides is described. ATPC is incorporated as N-terminal moiety in solution or solid-phase peptide synthesis using Boc or Fmoc methodology and without protection of the ATPC amino group. Georg Thieme Verlag Stuttgart.
