87476-73-1Relevant academic research and scientific papers
Rongalite-promoted metal-free aerobic ipso-hydroxylation of arylboronic acids under sunlight: DFT mechanistic studies
Golla, Sivaparwathi,Poshala, Soumya,Pawar, Ravinder,Kokatla, Hari Prasad
, (2019/12/27)
A novel rongalite-promoted metal-free aerobic ipso-hydroxylation of arylboronic acids has been developed. This method employs low-cost rongalite as a radical initiator and O2 as a green oxidizing agent for ipso-hydroxylation. This protocol is compatible with a wide variety of functional groups with good to excellent yields at room temperature. Furthermore, mechanistic insight into the role of superoxide radical anions in C-B cleavage has also been provided based on DFT studies.
Continuous-flow synthesis of functionalized phenols by aerobic oxidation of grignard reagents
He, Zhi,Jamison, Timothy F.
supporting information, p. 3353 - 3357 (2014/04/03)
Phenols are important compounds in chemical industry. An economical and green approach to phenol preparation by the direct oxidation of aryl Grignard reagents using compressed air in continuous gas-liquid segmented flow systems is described. The process tolerates a broad range of functional groups, including oxidation-sensitive functionalities such as alkenes, amines, and thioethers. By integrating a benzyne-mediated in-line generation of arylmagnesium intermediates with the aerobic oxidation, a facile three-step, one-flow process, capable of preparing 2-functionalized phenols in a modular fashion, is established. Putting on airs: Aerobic oxidation of (hetero)aryl Grignard reagents using compressed air proceeds with a gas-liquid continuous-flow system, thus enabling preparation of fucntionalized phenols. By integrating an in-line generation of ArMgBr intermediates with the aerobic oxidation, ortho-functionalized phenols can be assembled. The method demonstrates good functional-group (FG) compatibility, mild reaction conditions, and short reaction times.
SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF
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Page/Page column 390; 391, (2014/09/29)
Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.
SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF
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Paragraph 0320; 0321, (2014/09/30)
Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.
Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors
Sheng, Rong,Lin, Xiao,Li, Jingya,Jiang, Yanke,Shang, Zhicai,Hu, Yongzhou
, p. 3834 - 3837 (2007/10/03)
A series of 2-phenoxy-indan-1-one derivatives have been designed, synthesized, and tested as acetylcholinesterase inhibitors. The most potent compound exhibited high AChE inhibitory activity (IC50 = 50 nM), and the molecular docking study indicated that it was nicely accommodated by AChE.
BENZO-FUSED HETEROCYCLIC ANTI-ULCER AGENTS
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, (2008/06/13)
Compounds of the formula: STR1 wherein B is a moiety having the formula: STR2 R is mono-or dihalo, amino, nitro, cyano, hydroxy, trifluoromethyl, mercapto, lower alkyl, lower alkoxy, alkanoyl, cycloalkyl of 4-7 carbon atoms, carboxy, alkoxycarbonyl, mono-or di-lower alkyl substituted amino, alkanoylamino, lower alkyl thio, lower alkylsulfonyl, sulfamoyl, lower alkyl substituted sulfamoyl, phenyl or phenyl substituted with halo, lower alkyl, lower alkoxy, trifluoromethyl, hydroxy, amino, cyano or nitro.X is SO 2, SO, S or C=O; andA is amine selected from the group STR3 , wherein R 1 is hydrogen or R 2 CH 2 wherein R 2 is mono-or diloweralkylamino, mono-or di-N-lower alkylaminoloweralkyl, (2-furyl) methylamino, benzylamino, lowercycloalkylamino, 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 1-octahydroazocinyl, 3-thiazolidinyl, 4-morpholinyl or 4-thiomorpholinyl; R 3 is hydrogen or (1-piperidinyl) methyl with the proviso that when R 3 is (1-piperidinyl)methyl, R 1 is hydrogen; n is 1 to 4, and the pharmacologically acceptable salts thereof.
